Aging, noncommunicable diseases, physical performance, function and activity among people living with HIV in Ukraine

Oleksandr Zeziulin

01.09.2023 – 30.04.2025

National Institute of Health

The goal of this study is to create the foundation for: 1) a follow-up cohort study of PLWH, and 2) inform patient management practices to reduce NCD-associated morbidity and mortality among Ukrainian PLWH.

1. Characterize the pilot study sample using simple demographic variables (age, sex at birth, gender, etc.) as well as HIV and other infectious disease (ID) variables including history of AIDS, HIV viral load, current and nadir CD4+ counts and history of tuberculosis and HCV.

2. Assess physical performance, daily functioning and physical activity using the WHO International Classification of Functioning, Disability and Health; components of the Short Physical Performance Battery (4m walk, grip strength, and repeated chair stands); and WHO Global Physical Activity Questionnaire.

3. Measure NCDs including overweight, obesity, hypertension, T2D, and CVD; and mental health NCDs including depression, PTSD alcohol use disorder (AUD), and substance use disorder (SUD)..

4. Calculate cross-sectional associations of physical function, performance and activity with aging-related NCD outcomes, individually and in combination, and with consideration for HIV/ID factors, self-reported sociodemographic factors and medical history.